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The derivatization of metabolites deposited in solution onto a glass plate by dropping the derivatizing reagent on the top of the dried analytes was proposed by Lubin et al. [64]. The authors successfully applied this technique to several samples, demonstrating the possibility of performing multiple and subsequent derivatization steps on the same spot.


Innovations in PSI-MS have been described by Duarte et al. [88] and Salentijin et al. [89] who developed 3D-printed cartridges in order to obtain a solvent reservoir, thus allowing us to prolong the spray generation from the paper tip. A supporting prototype able to automatically perform PSI-MS analysis of a great number of samples, suitable for high-throughput applications, has been designed by Shen et al. [90]. Finally, the coupling of SFME with PSI-MS for the rapid analysis of macrolide antibiotics at the trace level in biological samples such as whole blood, milk, and other body fluids has been proposed in a study carried out by Deng et al. [91]. The same approach was applied for the detection of perfluorooctanesulfonic acid and perfluorooctanoic acid from Daphnia magna body fluids. After the SFME extraction, the organic extract was simply spotted on the PSI paper.

In the same year, Ewing et al. [110] described the DESI-MS detection of the low vapor pressure nerve agent simulant triethyl phosphate. The analyte was previously adsorbed onto silica gel, forming a very fine particulate that was collected by using a sticky screen sampler. The device was characterized by a stainless steel screen presenting a partially polymerized polydimethylsiloxane (PDMS) coating. The quantitative collection of the particulate sample from a contaminated surface was achieved by interfacing the sticky screen sampler with a bioaerosol collector. Finally, the sticky screen was placed onto a moveable platform mounted in front of the DESI-MS instrument, thus allowing a reproducible sample introduction system able to minimize sampling errors. DESI-MS analyses performed directly on the PDMS coating allowed us to obtain a very low detection limit suitable for trace detection.

Teresa Chavez is a beautiful and intelligent young woman, desperately seeking to leave the grinding poverty of the neighborhood where she lives, which causes her to have a miserable and resentful life despite her parents' love and support. After Rosa, her younger sister, dies from a heart disease, Teresa blames not having money for her sister's death. She vows that she will never be penniless again, making plans to escape the life of poverty surrounding her, using her beauty as a way to get out. She is in love with Mariano, a man who lives in the same neighborhood with her and is studying to become a doctor in order to meet Teresa's expectations and fulfill all her dreams, but Teresa is impatient.

Time passes and Arturo finds out that Teresa and Mariano made love the day before Arturo's wedding with Teresa, and that she only married him for his money. Arturo is then thrown into an economic crisis, and doubting the love of Teresa, decides to test her love and takes her to live in the same neighbourhood that she originated from. Tired of the economic crisis, Teresa seeks to improve their status and socio-economic position by seducing Fernando. Mariano finds out and tells Luisa about Teresa's attempt to conquer Fernando's heart, and he openly admits that he's in love with Teresa, breaking off their engagement days before their wedding. Heartbroken, Luisa slowly overcomes her pain and accepts Fernando's decision without any resentment and soon finds that she's pregnant with Fernando's child, through she makes it clear she doesn't want anything with him. Armando, Teresa's father, also finds out about his daughter's actions and, disappointed he dies of a heart attack. At this time, Teresa is now in love with Arturo, but at the same time, she believes that he should recover his status. Lucia, Luisa's real best friend, also likes Arturo, which not only proves Teresa's true love for him, but causes her to be extremely jealous of Lucia.

As the story develops, Teresa successfully seduces Fernando, and convinces him to leave Luisa and to sign over half of his fortune to her. During an interview for their wedding, Teresa turns against her family, stating that she comes from the same socio-economic background as Fernando, and that her parents had died and Juana, her godmother, was merely her nanny. Finally seeing Teresa's true colors, Juana and Refugio, Teresa's mother, are left heartbroken. Later, Teresa tries to justify the rejection saying she felt it was necessary for the interview. All of her friends and family turn against Teresa, criticizing her for preferring money over love. Although Teresa is left alone, she dumps Fernando once she gets his money and attempts to get back Arturo's love for her and forgiveness as she feels that he's her true love. When Arturo is involved in a car accident, Teresa searches for him and he is immediately transported to a nearby hospital. As he slowly recovers, he rejects her for not loving him earlier. Teresa donates all her half of Fernando's money to Paloma's foundation for children after Fernando rejected receiving the stolen fortune. As Teresa tries to correct her mistakes, Refugio denies it as she feels that it's too early to forgive Teresa and can't be sure if her daughter's change is sincere and Juana also refuses to forgive Teresa, leaving her all alone. Back at her house, realizing and accepting that she's been left alone with no loved ones around her, she goes to her room and cries while hugging the teddy bear that Arturo gave her as a gift while stating that she'll start over again. Arturo then appears, and he picks her up from the ground, hugs her and later, they both kiss. She learned what love really is while Arturo forgave her, giving her another chance. 041b061a72


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